, 2006; Sawaya and Kraut, 1997; Figure one—figure dietary supplement one), we predicted the mutational landscape of DHFR to get constrained through the prerequisite to undertake these distinctive conformations. Furthermore, prior operate experienced recommended DHFR is impacted by mobile constraints for example protein good quality Manage (Bershtein et al., 2013) as well as the Construct-up of a toxic metabolic intermediate (Schober et al., 2019). We as a result expected deep mutational scanning to expose a hugely constrained mutational landscape for DHFR that would contrast While using the mutational tolerance noticed in other techniques.
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